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Hence, in order to study the specific effect of combined ADH and CYP2E1 activity on chronic alcohol treatment in hepatocytes, VL-17A cells, which are HepG2 cells overexpressing both ADH and CYP2E1, have been established [31]

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Specific genetic mutations that cause abnormal protein accumulation cause neurodegenerative diseases like Alzheimers and Parkinsons both of which are common types of dementias that arise from certain parts of the brain decaying faster than others